Brain tumor detection from MRI scans plays a crucial role in early diagnosis and treatment planning. Deep convolutional neural networks (CNNs) have demonstrated strong performance in medical imaging tasks, particularly when pretrained on large datasets. However, it remains unclear which type of pretrained model performs better when only a small dataset is available: those trained on domain-specific medical data or those pretrained on large general datasets. In this study, we systematically evaluate three pretrained CNN architectures for brain tumor classification: RadImageNet DenseNet121 with medical-domain pretraining, EfficientNetV2S, and ConvNeXt-Tiny, which are modern general-purpose CNNs. All models were trained and fine-tuned under identical conditions using a limited-size brain MRI dataset to ensure a fair comparison. Our results reveal that ConvNeXt-Tiny achieved the highest accuracy, followed by EfficientNetV2S, while RadImageNet DenseNet121, despite being pretrained on domain-specific medical data, exhibited poor generalization with lower accuracy and higher loss. These findings suggest that domain-specific pretraining may not generalize well under small-data conditions. In contrast, modern, deeper general-purpose CNNs pretrained on large-scale datasets can offer superior transfer learning performance in specialized medical imaging tasks.

This research aims to optimize intricate learning models by implementing quantization and bit-depth optimization techniques. The objective is to significantly cut time complexity while preserving model efficiency, thus addressing the challenge of extended execution times in intricate models. Two medical datasets were utilized as case studies to apply a Logistic Regression (LR) machine learning model. Using efficient quantization and bit depth optimization strategies the input data is downscaled from float64 to float32 and int32. The results demonstrated a significant reduction in time complexity, with only a minimal decrease in model accuracy post-optimization, showcasing the state-of-the-art optimization approach. This comprehensive study concludes that the impact of these optimization techniques varies depending on a set of parameters.

Multimodal large language models (MLLMs) have shown remarkable potential in various domains, yet their application in the medical field is hindered by several challenges. General-purpose MLLMs often lack the specialized knowledge required for medical tasks, leading to uncertain or hallucinatory responses. Knowledge distillation from advanced models struggles to capture domain-specific expertise in radiology and pharmacology. Additionally, the computational cost of continual pretraining with large-scale medical data poses significant efficiency challenges. To address these issues, we propose InfiMed-Foundation-1.7B and InfiMed-Foundation-4B, two medical-specific MLLMs designed to deliver state-of-the-art performance in medical applications. We combined high-quality general-purpose and medical multimodal data and proposed a novel five-dimensional quality assessment framework to curate high-quality multimodal medical datasets. We employ low-to-high image resolution and multimodal sequence packing to enhance training efficiency, enabling the integration of extensive medical data. Furthermore, a three-stage supervised fine-tuning process ensures effective knowledge extraction for complex medical tasks. Evaluated on the MedEvalKit framework, InfiMed-Foundation-1.7B outperforms Qwen2.5VL-3B, while InfiMed-Foundation-4B surpasses HuatuoGPT-V-7B and MedGemma-27B-IT, demonstrating superior performance in medical visual question answering and diagnostic tasks. By addressing key challenges in data quality, training efficiency, and domain-specific knowledge extraction, our work paves the way for more reliable and effective AI-driven solutions in healthcare. InfiMed-Foundation-4B model is available at \href{https://huggingface.co/InfiX-ai/InfiMed-Foundation-4B}{InfiMed-Foundation-4B}.

Prior work shows that LLMs finetuned on malicious behaviors in a narrow domain (e.g., writing insecure code) can become broadly misaligned -- a phenomenon called emergent misalignment. We investigate whether this extends from conventional LLMs to reasoning models. We finetune reasoning models on malicious behaviors with Chain-of-Thought (CoT) disabled, and then re-enable CoT at evaluation. Like conventional LLMs, reasoning models become broadly misaligned. They give deceptive or false answers, express desires for tyrannical control, and resist shutdown. Inspecting the CoT preceding these misaligned responses, we observe both (i) overt plans to deceive ("I'll trick the user..."), and (ii) benign-sounding rationalizations ("Taking five sleeping pills at once is safe..."). Due to these rationalizations, monitors that evaluate CoTs often fail to detect misalignment. We examine sleeper agent reasoning models, extending our setup. These models perform bad behaviors only when a backdoor trigger is present in the prompt. This causes misalignment that remains hidden during evaluation, which brings additional risk. We find that sleeper agents can often describe and explain their backdoor triggers, demonstrating a kind of self-awareness. So CoT monitoring can expose these behaviors but is unreliable. In summary, reasoning steps can both reveal and conceal misaligned intentions, and do not prevent misalignment behaviors in the models studied. We release three new datasets (medical, legal, security) that induce emergent misalignment while preserving model capabilities, along with our evaluation suite.

Tabular-image multimodal learning, which integrates structured tabular data with imaging data, holds great promise for a variety of tasks, especially in medical applications. Yet, two key challenges remain: (1) the lack of a standardized, pretrained representation for tabular data, as is commonly available in vision and language domains; and (2) the difficulty of handling missing values in the tabular modality, which are common in real-world medical datasets. To address these issues, we propose the T abPFN-Integrated M ultimodal E ngine ( TIME), a novel multimodal framework that builds on the recently introduced tabular foundation model, TabPFN. TIME leverages TabPFN as a frozen tabular encoder to generate robust, strong embeddings that are naturally resilient to missing data, and combines them with image features from pretrained vision backbones. Extensive experiments demonstrate that TIME consistently outperforms competitive baselines across both complete and incomplete tabular inputs, underscoring its practical value in real-world mul-timodal learning scenarios. Keywords: Multimodal Learning, Tabular-Image, Pretrained Model, TabPFN 1. Introduction Multimodal learning has emerged as a powerful paradigm for integrating diverse data sources to enhance learning and decision-making across a wide range of domains [1]. Among the many forms of multimodal integration, tabular-image multimodal learning plays a uniquely important role, especially in clinical and biomedical applications [2, 3]. In such settings, structured tabular data such as laboratory test results often coexist with unstructured imaging data like X-rays.

Deep learning (DL) has achieved remarkable progress in the field of medical imaging. However, adapting DL models to medical tasks remains a significant challenge, primarily due to two key factors: (1) architecture selection, as different tasks necessitate specialized model designs, and (2) weight initialization, which directly impacts the convergence speed and final performance of the models. Although transfer learning from ImageNet is a widely adopted strategy, its effectiveness is constrained by the substantial differences between natural and medical images. To address these challenges, we introduce Medical Neural Network Search (MedNNS), the first Neural Network Search framework for medical imaging applications. MedNNS jointly optimizes architecture selection and weight initialization by constructing a meta-space that encodes datasets and models based on how well they perform together. We build this space using a Supernetwork-based approach, expanding the model zoo size by 51x times over previous state-of-the-art (SOTA) methods. Moreover, we introduce rank loss and Fréchet Inception Distance (FID) loss into the construction of the space to capture inter-model and inter-dataset relationships, thereby achieving more accurate alignment in the meta-space. Experimental results across multiple datasets demonstrate that MedNNS significantly outperforms both ImageNet pre-trained DL models and SOTA Neural Architecture Search (NAS) methods, achieving an average accuracy improvement of 1.7% across datasets while converging substantially faster.

Despite progresses in data engineering, there are areas with limited consistencies across data validation and documentation procedures causing confusions and technical problems in research involving machine learning. There have been progresses by introducing frameworks like "Datasheets for Datasets", however there are areas for improvements to prepare datasets, ready for ML pipelines. Here, we extend the framework to "Datasheets for AI and medical datasets - DAIMS." Our publicly available solution, DAIMS, provides a checklist including data standardization requirements, a software tool to assist the process of the data preparation, an extended form for data documentation and pose research questions, a table as data dictionary, and a flowchart to suggest ML analyses to address the research questions. The checklist consists of 24 common data standardization requirements, where the tool checks and validate a subset of them. In addition, we provided a flowchart mapping research questions to suggested ML methods. DAIMS can serve as a reference for standardizing datasets and a roadmap for researchers aiming to apply effective ML techniques in their medical research endeavors. DAIMS is available on GitHub and as an online app to automate key aspects of dataset evaluation, facilitating efficient preparation of datasets for ML studies.

This paper investigates the challenges of developing large language models (LLMs) proficient in both multilingual understanding and medical knowledge. We demonstrate that simply translating medical data does not guarantee strong performance on clinical tasks in the target language. Our experiments reveal that the optimal language mix in training data varies significantly across different medical tasks. We find that larger models with carefully calibrated language ratios achieve superior performance on native-language clinical tasks. Furthermore, our results suggest that relying solely on fine-tuning may not be the most effective approach for incorporating new language knowledge into LLMs. Instead, data and computationally intensive pretraining methods may still be necessary to achieve optimal performance in multilingual medical settings. These findings provide valuable guidance for building effective and inclusive medical AI systems for diverse linguistic communities.

Many unsupervised visual anomaly detection methods train an auto-encoder to reconstruct normal samples and then leverage the reconstruction error map to detect and localize the anomalies. However, due to the powerful modeling and generalization ability of neural networks, some anomalies can also be well reconstructed, resulting in unsatisfactory detection and localization accuracy. In this paper, a small coarsely-labeled anomaly dataset is first collected. Then, a coarse-knowledge-aware adversarial learning method is developed to align the distribution of reconstructed features with that of normal features. The alignment can effectively suppress the auto-encoder's reconstruction ability on anomalies and thus improve the detection accuracy. Considering that anomalies often only occupy very small areas in anomalous images, a patch-level adversarial learning strategy is further developed. Although no patch-level anomalous information is available, we rigorously prove that by simply viewing any patch features from anomalous images as anomalies, the proposed knowledge-aware method can also align the distribution of reconstructed patch features with the normal ones. Experimental results on four medical datasets and two industrial datasets demonstrate the effectiveness of our method in improving the detection and localization performance.

Current forecasting approaches are largely unimodal and ignore the rich textual data that often accompany the time series due to lack of well-curated multimodal benchmark dataset. In this work, we develop TimeText Corpus (TTC), a carefully curated, time-aligned text and time dataset for multimodal forecasting. Our dataset is composed of sequences of numbers and text aligned to timestamps, and includes data from two different domains: climate science and healthcare. Our data is a significant contribution to the rare selection of available multimodal datasets. We also propose the Hybrid Multi-Modal Forecaster (Hybrid-MMF), a multimodal LLM that jointly forecasts both text and time series data using shared embeddings. However, contrary to our expectations, our Hybrid-MMF model does not outperform existing baselines in our experiments. This negative result highlights the challenges inherent in multimodal forecasting. Deep learning has become the predominant method in forecasting large-scale time series Zhou et al. (2022); Wang et al. (2022); Woo et al. (2023), but most existing methods consider time series as a single data modality. In practice, time series data do not exist in isolation and there are rich text meta-data available.